1.Wang YJ#*, Yu C#, Wu WW#, Ju YY, Liu Y, Xu C, Long JD, Zan GY, Wei XY, Zhang LS, Chai JR, Chen Z*, Liu JG*. Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory. Mol Psychiatry 2021. 

2.Chen ZG#, Wang YJ#, Chen RS#, Geng F, Gan CL, Wang WS, Liu X, Zhou H, He L, Hu G*, Liu JG*. Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity. Mol Psychiatry 2021, 26:1162-1177. 

3.Zan GY#, Wang YJ#*, Li XP#, Fang JF, Yao SY, Du JY, Wang Q, Sun X, Liu R, Shao XM, Long J D, Chai JR, Deng YZ, Chen YQ, Li QL, Fang JQ, Liu ZQ*，Liu JG*. Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence. Cell Rep 2021, 37, 109913, doi:10.1016/j.celrep.2021.109913.

4.Zhang L#, Kibaly C#, Wang YJ#, Xu C, Song KY, McGarrah PW, Loh HH, Liu JG*, Law PY*. Src-dependent phosphorylation of mu-opioid receptor at Tyr(336) modulates opiate withdrawal. EMBO Mol Med 2017, 9:1521-1536. 

5.Kong LH, Shu X, Tang S, Ye R, Sun H, Jiang S, Li Z, Chai J, Fang Y, Lan Y, Yu L, Xie Q, Fu W, Wang YJ*, Li W*, Qiu Z, Liu JG*, Shao L*. SLL-627 is a highly selective and potent k opioid receptor (KOR) agonist with an Unexpercted Noreduction in Locomotor activity. J Med Chem, 2022. 65 (15), 10377-10392

6.He Q, Wei Y, Liu X, Ye R, Kong L, Li Z, Jiang S, Yu L, Chai J, Xie Q, W, Wang YJ*, Li W*, Qiu Z, Liu JG*, Shao L*. Discovery of an m substituted N cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a selective, potent, and orally active κ opioid receptor agonist with an improved central nervous system safety profile. J Med Chem 2021, 64(16), 12414–12433. 

7.Huang H#, Li X#, Xie P#, Li X, Xu X, Qian Y, Yuan C, Meng X, Chai J, Chen J, Liu J, Wang W, Li W*, Wang Y*, Fu W*, Liu JG. (2021) Discovery, Structure-Activity Relationship and Mechanism Studies of 1-((3R, 4S)-3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as Novel Potent Analgesic. J Med Chem 2021 Accepted 

8.Xiao L#, Wang Y#, Zhang M#, Wu W#, Kong L, Ma Y, Xu X, Liu X, He Q, Qian Y, Sun H, Wu H, Lin C, Huang H, Ye R, Jiang S, Ye RF, Yuan C, Fang S, Xue D, Yang X, Chen H, Zheng Y, Yu L, Xie Q, Zheng L, Fu W, Li W*, Qiu Z, Liu J*, Shao L*. Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept. J Med Chem 2019, 62:11054-11070. 

9.Lu YC; Wang YJ*; Lu B; Chen M; Zheng P; Liu JG*. ACC to Dorsal Medial Striatum Inputs Modulate Histaminergic Itch Sensation. Journal of Neuroscience, 2018, 38(15): 3823-3839

10.Tao YM#, Yu C#, Wang WS, Hou YY, Xu XJ, Chi ZQ, Ding YQ, Wang YJ*, Liu JG*. Heteromers of mu opioid and dopamine D1 receptors modulate opioid-induced locomotor sensitization in a dopamine-independent manner. Br J Pharmacol 2017, 174:2842-2861. 

11.Deng YZ, Lu YC, Wu WW, Cheng L, Zan GY, Chai JR, Wang YJ*, Chen Z, Liu JG. Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation. Neuropharmacology 2020, 168:108028 

12.Wang YJ, Hang A, Lu YC, Long Y, Zan GY, Li XP, He L, Chi ZQ, Liu JG. Opioid receptor activation in different brain regions differentially modulate anxiety-related behaviors in mice. Neuropharmacol, 2016, doi: 10.1016/j.neuropharm.2016.04.022. 

13.Zhang LS#, Wang YJ#, Ju YY, Zan GY, Xu C, Hong MH, Wang YH, Chi ZQ, Liu JG. Role for engagement of β-arrestin 2 by the transactivated EGFR in agonist-specific regulation of δ receptor activation of ERK1/2. Brit J Pharmacol, 2015, 172(20):4847-4863

14.Wang YJ, Huang P, Blendy J and Liu-Chen LY. Brain region- and sex-specific alterations of DAMGO-stimulated [35S]GTPgS binding in mice with Oprm1 A112G. Addict. Biol, 2012. doi: 10.1111/j.1369-1600.2012.00484.x

15.Wang YJ, Huang P, Ung A, Blendy J and Liu-Chen LY. Reduced expression of the mu opioid receptor in some, but not all, brain regions in mice with Oprm1 A112G. Neuroscience, 2012, 205:178-84.

16.Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A, Liu-Chen L-Y. Sex difference in kappa opioid receptor (KOPR)-mediated behaviors and brain region KOPR level and KOPR-mediated [35S]GTPgS binding in the guinea pig. J Pharmacol Exp Ther, 2011, 339:438-450.

17.Wang YJ, Tao YM, Li FY, Wang YH, Xue XJ, Chen J, Cao YL, Chi ZQ, Neumeyer JL, Zhang A, Liu-JG. Pharmacological characterization of ATPM, a novel mixed κ agonist and μ agonist/antagonist that attenuates morphine antinociceptive tolerance and heroin self-administration behavior. J Pharmacol Exp Ther, 2008. 329(1): 306-13

18.Lin X#, Wang YJ#, Li Q, Hou YY, Hong MH, Cao YL, Chi ZQ, Liu JG. Chronic high-dose Morphine treatment Promotes SH-SY5Y Cell Apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway. FEBS J, 2008, 276(7): 2022-36