1.Peiyu Xu, Sijie Huang, Shimeng Guo, Ying Yun, Xi Cheng, Xinheng He, Pengjun Cai, Yuan Lan, Hu Zhou, Hualiang Jiang, Yi Jiang*, Xin Xie*, H. Eric Xu*. Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nature Structural & Molecular Biology. 2022 Aug 15. doi: 10.1038/s41594-022-00816-5. Online ahead of print.

2.Ren Guo, Xiaohui Jia, Zhenbin Ding, Gang Wang, Mengmeng Jiang, Bing Li, Shanshan Chen, Bingqing Xia, Qing Zhang, Jian Liu, Ruting Zheng, Zhaobing Gao, Xin Xie*. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation. Theranostics. 2022, 12(11): 5220-5236. doi: 10.7150/thno.71400 

3.Suo N, He B, Cui S, Yang Y, Wang M, Yuan Q, Xie X*. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia. 2022 Jun 27. doi: 10.1002/glia.24233. Online ahead of print.

4.Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H*, Zhang Y*, Xie X*, Jiang Y*. Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nat Commun. 2022 Mar 15;13(1):1364.

5.Chen LH, Zhang Q, Xiao YF, Fang YC, Xie X*, Nan FJ*. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022 Mar 10;65(5):3991-4006. doi: 10.1021/acs.jmedchem.1c01813. Epub 2022 Feb 23.

6.Qing Zhang#, Linhai Chen#, Hui Yang#, Youchen Fang, Siwei Wang, Min Wang, Qianting Yuan, Wei Wu, Yangming Zhang, Zhanju Liu*, Fajun Nan*, Xin Xie*. GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages. Acta Pharmacologica Sinica, 2022 Aug;43(8):2042-2054. doi: 10.1038/s41401-021-00825-y. Epub 2021 Dec 15.

7.Yun Y, Zhang C, Guo S, Liang X, Lan Y, Wang M, Zhuo N, Yin J, Liu H, Gu M, Li J, Xie X*, Nan F*. Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5 H88Y Mutant Mice. J Med Chem. 2021 Aug 26;64(16):12181-12199.

8.Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE*, Xie X*, Jiang Y*. Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun. 2021 Aug 20;12(1):5064.

9.Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP*, Xie X*, Yu X*, Zhang Y*. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Jul 22. doi: 10.1038/s41586-020-2569-1.

10.Na Suo, Yu-e Guo, Bingqing He, Haifeng Gu, Xin Xie*. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia, 2019 Jul;67(7):1320-1332.

11.Chenwen Huang, Wanzhi Tu, Yanbin Fu, Xin Xie*. Chemical-induced cardiac reprogramming in vivo. Cell Research, 2018 Jun;28(6):686-689.

12.Haikun Song, Hexuan Li, Shimeng Guo, Yuyin Pan, Yuhua Fu, Zijian Zhou, Zhaoyang Li, Xue Wen, Xiaoli Sun, Bingqing He, Haifeng Gu, Youhong Hu, Xin Xie*, Boxun Lu*. Targeting Gpr52 Lowers Mutant HTT Levels and Rescues Huntington’s Disease-associated Phenotypes. Brain, 2018 Jun 1;141(6):1782-1798.

13.Ren Guo, Wei Tang, Qianting Yuan, Lijian Hui, Xin Wang, Xin Xie*. Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor, Stem Cell Reports, 2017, Aug 8;9(2):499-512.

14.Jiali Jin, Jian Liu, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie*, Ping Wang*. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications, 2016 Nov 25;7:13594.

15.Changsheng Du, Yanhui Duan, Hui Chai, Yingying Cai, Wei Wei, Jie Lv, Xin Xie*. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.Nature Communications, 2016 Apr 4;7:11120.

16.Yuan Long, Min Wang, Haifeng Gu, Xin Xie*. Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells. Cell Research, 2015 Oct;25(10):1171-4.

17.Yanbin Fu, Chenwen Huang, Xinxiu Xu, Haifeng Gu, Youqiong Ye, Cizhong Jiang, Zilong Qiu, Xin Xie*. Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Research, 2015 Sep;25(9):1013-24.

18.Kong X, Liu J, Li L, Yue L, Zhang L, Jiang H, Xie X*, Luo C*. Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition. Nucleic Acids Research, 2015 May 19; 43(9):4381-92.

19.Shuyong Zhang, Yuyong Ma, Jing Li, Biao Yu*, Xin Xie*. Molecular matchmaking between the popular ‘weight loss’ herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorders. Proc Natl Acad Sci U S A, 2014 Oct 7;111(40):14571-6.

20.Guofang Chen, Xinxiu Xu, Lihong Zhang, Yanbin Fu, Min Wang, Haifeng Gu, Xin Xie*. Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cells self-renewal and somatic cell reprogramming. Cell Research, 2014 Sep;24(9):1121-36.

21.Xiaoyuan Wei, Yueting Chen, Yongyu Xu, Yang Zan, Ru Zhang, Min Wang, Qiuhong Hua, Haifeng Gu, Fajun Nan*, Xin Xie*. Small molecule compound induces chromatin de-condensation and facilitate induced pluripotent stem cell generation. Journal of Molecular Cell Biology, 2014 Oct;6(5):409-20.

22.Yongyu Xu, Xiaoyuan Wei, Min Wang, Ru Zhang*, Yanbin Fu, Mingzhe Xing, Qiuhong Hua, Xin Xie*. Proliferation rate of somatic cells affects reprogramming efficiency. Journal of Biological Chemistry. 2013, Apr 5;288(14):9767-78.

23.Feifei Zhang, Wei Wei, Hui Chai, Xin Xie*. Aurintricarboxylic Acid Ameliorates Experimental Autoimmune Encephalomyelitis by Blocking Chemokine-mediated Pathogenic Cell Migration and Infiltration. Journal of Immunology. 2013 Feb 1;190(3):1017-25.

24.Wei Wei, Changsheng Du, Jie Lv, Guixian Zhao, Zhenxin Li, Zhiying Wu, G Haskó, Xin Xie*. Blocking A2B Adenosine Receptor alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and TH-17 Differentiation. Journal of Immunology. 2013 Jan 1;190(1):138-46.

25.Xinxiu Xu, Quan Wang, Yuan Long, Ru Zhang, Xiaoyuan Wei, Mingzhe Xing, Haifeng Gu, Xin Xie*. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Research. 2013 Jan;23(1):131-41.

26.Jie Lv, Changsheng Du, Wei Wei, Zhiying Wu, Guixian Zhao, Zhenxin Li, Xin Xie*. The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. Journal of Biological Chemistry.2012 Aug 17; 287(34):28656-65.

27.Chang-Sheng Du, Xin Xie*. G Protein-Coupled Receptors as Therapeutic Targets for Multiple Sclerosis. Cell Research. 2012 Jul; 22(7):1108-28.

28.Liefeng Wang, Changsheng Du, Jie Lv, Wei Wei, Ye Cui, Xin Xie*. Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis. Journal of Immunology. 2011;187(5):2336-45.

29.Quan Wang, Xinxiu Xu, Jun Li, Jing Liu, Haifeng Gu, Ru Zhang, Jiekai Chen, Yin Kuang, Jian Fei, Cong Jiang, Ping Wang, Duanqing Pei, Sheng Ding, Xin Xie*. Lithium, an anti-Psychotic Drug, Greatly Enhances the Generation of Induced Pluripotent Stem Cells. Cell Research. 2011;21(10):1424-35.

30.He X, Fang L, Wang J, Yi Y, Zhang S, Xie X*. Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Research 2008 Nov 1; 68(21):8678-86.