研究生教育

药物化学

范耀月

姓 名 范耀月 性 别 职 称 研究员、博导
学 历 博士 电 话 传 真
电子邮件 yyfan@simm.ac.cn 个人主页 主页链接 专家类别
职 务 课题组长、博导
通讯地址 烟台市牟平区滨海东路198号
个人简介

范耀月,中科环渤海(烟台)药物高等研究院研究员、课题组长,优青。2015年博士毕业于中科院上海药物研究所,师从岳建民院士,同年留所工作,分别担任助理研究员、副研究员、研究员、课题组长。长期从事天然药物化学研究,已对多种陆地药用植物进行了系统深入的化学成分和生物活性研究,重点关注新骨架以及活性天然分子的发现与研究。2015年至今,已在国际知名期刊 J. Am. Chem. Soc.,Angew. Chem. Int. Ed., Org. Lett.,Sci. China: Chem.等以 作者或通讯作者发表多篇SCI论文。

工作经历

      2022.8-至今

      中科环渤海(烟台)药物高等研究院, 研究员、课题组长

      2022.1-2022.7

      上海药物研究所,民族药物与生物功能分子研究中心,研究员

      2018.10-2021.12

      上海药物研究所,天然药物化学室,副研究员

      2015.7-2018.9

      上海药物研究所,天然药物化学室,助理研究员 


     
     
     
     
研究方向

1.药用植物中结构新颖重要活性天然化合物的发现

2.基于天然产物的药物先导化合物发现与成药性研究

3.重要活性天然分子的药理作用机制和作用靶点研究


科研项目
科研成果

1. 自然科学基金 青年科学基金项目,天然药物化学,2022.01-2024.12,课题负责人

2. 自然科学基金面上项目,免疫抑制活性新颖结构三萜类分子的发现与研究,2018.01-2021.12,课题负责人

3.上海市青年科技启明星计划(A类),2019.04 -2022.03(人才基金)

4.中国科学院青年创新促进会会员,2018.01-2021.12(人才基金)


荣誉获奖

    2021-至今,Natural Products and Bioprospecting期刊青年编委

代表论著

      1.Yao-Yue Fan, Hua Zhang, Yu Zhou, Hong-Bing Liu, Wei Tang, Bin Zhou, Jian-Ping Zuo, and Jian-Min Yue*, Phainanoids A–F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis,Journal of the American Chemical Society, 2015, 137(1), 138-141. (IF = 16.3) 

      2.Zhan-Peng Ge#, Yao-Yue Fan#, Wen-De Deng, Cheng-Yu Zheng, Ting Li, Jian-Min Yue*, Cephalodiones A–D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition, Angewandte Chemie, International Edition, 2021, 60, 9374. (IF = 16.8,#Co-first author)

      3.Yao-Yue Fan, Xin-Hua Gao, and Jian-Min Yue*, Attractive natural products with strained cyclopropane and/or cyclobutane ring systems, Science China-Chemistry, 2016, 59(9), 1126-1141. (IF = 10.1)

      4.Yao-Yue Fan#, Shu-Qin Shi#, Guo-Zhen Deng, Hong-Chun Liu, Cheng-Hui Xu, Jian Ding, Guan-Wu Wang*, and Jian-Min Yue*, Crokonoids A–C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis, Organic Letters, 2020, 22(3), 929-933. (IF = 6.1,#Co-first author)

      5.Yu-Hao Ren, Qun-Fang Liu, Li Chen, Shi-Jun He, Jian-Ping Zuo, Yao-Yue Fan*, and Jian-Min Yue*, Urceoloids A and B, Two C19 Steroids with a Rearranged Spirocyclic Carbon Skeleton from Urceola quintaretii, Organic Letters, 2019, 21(6), 1904–1907.

      6.Yao-Yue Fan, Yi-Li Sun, Bin Zhou, Jin-Xin Zhao, Li Sheng, Jing-Ya Li*, and Jian-Min Yue*,Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale, Organic Letters, 2018, 20(17), 5435-5438.

      7.Yao-Yue Fan, Li-She Gan, Hong-Chun Liu, Heng Li, Cheng-Hui Xu, Jian-Ping Zuo, Jian Ding*, and Jian-Min Yue*, Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis, Organic Letters, 2017, 19(17), 4580-4583.

      8.Qi Jing Jing, Zhang Yan, Liu Qun Fang, Liu Hong Chun*, Fan Yao Yue*, Yue Jian Min*, Chinese Journal of chemistry, 2021, 39(7), 1891. (IF = 5.6)

      9.Jin-Biao Xu#, Yao-Yue Fan#, Li-She Gan, Yu-Bo Zhou, Jia Li, and Jian-Min Yue*, Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis, Chemistry - A European Journal, 2016, 22(41), 14648-14654. (IF = 5.0,#Co-first author)

      10.Yao-Yue Fan, Li-She Gan, Shi-Xin Chen, Qi Gong, Hai-Yan Zhang, and Jian-Min Yue*, Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale, Journal of Organic Chemistry, 2021, 86(16), 11277–11283. (IF = 4.0)

      11.Song Li#, Jin-Hai Yu#, Yao-Yue Fan#, Qun-Fang Liu, Zhan-Chao Li, Zhi-Xiang Xie, Ying Li, and Jian-min Yue*, Structural Elucidation and Total Synthesis of Three 9‑Norlignans from Curculigo capitulate, Journal of Organic Chemistry, 2019, 84(9), 5195-5202.(#Co-first author)

      12.Yu Ren, Xiao Tong, Ye Zhao, Shi-Jun He, Yao-Yue Fan*, and Jian-Min Yue*  Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense, Journal of Natural Products, 2022, 85(6), 1581-1590. (IF = 4.8)

      13.Zhan-Peng Ge, Hong-Chun Liu, Guo-Cai Wang, Qun-Fang Liu, Cheng-Hui Xu, Jian Ding, Yao-Yue Fan*, and Jian-Min Yue*, 17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortune, Journal of Natural Products, 2019, 82(6), 1565-1575.

      14.Yao-Yue Fan#, Jin-Biao Xu#, Hong-Chun Liu, Li-She Gan, Jian Ding, and Jian-Min Yue*, Cephanolides A–J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis, Journal of Natural Products, 2017, 80(12), 3159-3166.(#Co-first author)


社会任职

范耀月

姓 名 范耀月 性 别 职 称 研究员、博导
学 历 博士 电 话 传 真
电子邮件 yyfan@simm.ac.cn 个人主页 主页链接 专家类别
职 务 课题组长、博导
通讯地址 烟台市牟平区滨海东路198号
个人简介

    范耀月,中科环渤海(烟台)药物高等研究院研究员、课题组长,优青。2015年博士毕业于中科院上海药物研究所,师从岳建民院士,同年留所工作,分别担任助理研究员、副研究员、研究员、课题组长。长期从事天然药物化学研究,已对多种陆地药用植物进行了系统深入的化学成分和生物活性研究,重点关注新骨架以及活性天然分子的发现与研究。2015年至今,已在国际知名期刊 J. Am. Chem. Soc.,Angew. Chem. Int. Ed., Org. Lett.,Sci. China: Chem.等以 作者或通讯作者发表多篇SCI论文。

工作经历

      2022.8-至今

      中科环渤海(烟台)药物高等研究院, 研究员、课题组长

      2022.1-2022.7

      上海药物研究所,民族药物与生物功能分子研究中心,研究员

      2018.10-2021.12

      上海药物研究所,天然药物化学室,副研究员

      2015.7-2018.9

      上海药物研究所,天然药物化学室,助理研究员 


     
     
     
     
研究方向

    1.药用植物中结构新颖重要活性天然化合物的发现

    2.基于天然产物的药物先导化合物发现与成药性研究

    3.重要活性天然分子的药理作用机制和作用靶点研究


科研项目
科研成果

    1. 自然科学基金 青年科学基金项目,天然药物化学,2022.01-2024.12,课题负责人

    2. 自然科学基金面上项目,免疫抑制活性新颖结构三萜类分子的发现与研究,2018.01-2021.12,课题负责人

    3.上海市青年科技启明星计划(A类),2019.04 -2022.03(人才基金)

    4.中国科学院青年创新促进会会员,2018.01-2021.12(人才基金)


荣誉获奖

    2021-至今,Natural Products and Bioprospecting期刊青年编委

代表论著

    1.Yao-Yue Fan, Hua Zhang, Yu Zhou, Hong-Bing Liu, Wei Tang, Bin Zhou, Jian-Ping Zuo, and Jian-Min Yue*, Phainanoids A–F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis,Journal of the American Chemical Society, 2015, 137(1), 138-141. (IF = 16.3) 

    2.Zhan-Peng Ge#, Yao-Yue Fan#, Wen-De Deng, Cheng-Yu Zheng, Ting Li, Jian-Min Yue*, Cephalodiones A–D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition, Angewandte Chemie, International Edition, 2021, 60, 9374. (IF = 16.8,#Co-first author)

    3.Yao-Yue Fan, Xin-Hua Gao, and Jian-Min Yue*, Attractive natural products with strained cyclopropane and/or cyclobutane ring systems, Science China-Chemistry, 2016, 59(9), 1126-1141. (IF = 10.1)

    4.Yao-Yue Fan#, Shu-Qin Shi#, Guo-Zhen Deng, Hong-Chun Liu, Cheng-Hui Xu, Jian Ding, Guan-Wu Wang*, and Jian-Min Yue*, Crokonoids A–C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis, Organic Letters, 2020, 22(3), 929-933. (IF = 6.1,#Co-first author)

    5.Yu-Hao Ren, Qun-Fang Liu, Li Chen, Shi-Jun He, Jian-Ping Zuo, Yao-Yue Fan*, and Jian-Min Yue*, Urceoloids A and B, Two C19 Steroids with a Rearranged Spirocyclic Carbon Skeleton from Urceola quintaretii, Organic Letters, 2019, 21(6), 1904–1907.

    6.Yao-Yue Fan, Yi-Li Sun, Bin Zhou, Jin-Xin Zhao, Li Sheng, Jing-Ya Li*, and Jian-Min Yue*,Hedyorienoids A and B, Two Sesquiterpenoid Dimers Featuring Different Polycyclic Skeletons from Hedyosmum orientale, Organic Letters, 2018, 20(17), 5435-5438.

    7.Yao-Yue Fan, Li-She Gan, Hong-Chun Liu, Heng Li, Cheng-Hui Xu, Jian-Ping Zuo, Jian Ding*, and Jian-Min Yue*, Phainanolide A, Highly Modified and Oxygenated Triterpenoid from Phyllanthus hainanensis, Organic Letters, 2017, 19(17), 4580-4583.

    8.Qi Jing Jing, Zhang Yan, Liu Qun Fang, Liu Hong Chun*, Fan Yao Yue*, Yue Jian Min*, Chinese Journal of chemistry, 2021, 39(7), 1891. (IF = 5.6)

    9.Jin-Biao Xu#, Yao-Yue Fan#, Li-She Gan, Yu-Bo Zhou, Jia Li, and Jian-Min Yue*, Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis, Chemistry - A European Journal, 2016, 22(41), 14648-14654. (IF = 5.0,#Co-first author)

    10.Yao-Yue Fan, Li-She Gan, Shi-Xin Chen, Qi Gong, Hai-Yan Zhang, and Jian-Min Yue*, Horienoids A and B, Two Heterocoupled Sesquiterpenoid Dimers from Hedyosmum orientale, Journal of Organic Chemistry, 2021, 86(16), 11277–11283. (IF = 4.0)

    11.Song Li#, Jin-Hai Yu#, Yao-Yue Fan#, Qun-Fang Liu, Zhan-Chao Li, Zhi-Xiang Xie, Ying Li, and Jian-min Yue*, Structural Elucidation and Total Synthesis of Three 9‑Norlignans from Curculigo capitulate, Journal of Organic Chemistry, 2019, 84(9), 5195-5202.(#Co-first author)

    12.Yu Ren, Xiao Tong, Ye Zhao, Shi-Jun He, Yao-Yue Fan*, and Jian-Min Yue*  Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense, Journal of Natural Products, 2022, 85(6), 1581-1590. (IF = 4.8)

    13.Zhan-Peng Ge, Hong-Chun Liu, Guo-Cai Wang, Qun-Fang Liu, Cheng-Hui Xu, Jian Ding, Yao-Yue Fan*, and Jian-Min Yue*, 17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortune, Journal of Natural Products, 2019, 82(6), 1565-1575.

    14.Yao-Yue Fan#, Jin-Biao Xu#, Hong-Chun Liu, Li-She Gan, Jian Ding, and Jian-Min Yue*, Cephanolides A–J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis, Journal of Natural Products, 2017, 80(12), 3159-3166.(#Co-first author)


社会任职