课题组长-中科环渤海（烟台）药物高等研究院

程震

姓名	程震	性别	男	职称	研究员
学历	博士	电话		传真
电子邮件	zcheng@simm.ac.cn	个人主页	主页链接	专家类别
职务	中心主任、课题组长
通讯地址	烟台市牟平区滨海东路198号

研究方向

1. 肿瘤分子影像及多模态分子探针的研发

2. 放射性药物研发

3. 纳米医学

科研项目

近红外二区成像设备研发

科研成果

1.Cheng Z*, Hong X, Dai H, Chen H, Antaris A, Cheng K, “Small molecule dye for molecular imaging and photothermal therapy”. US10894121B2, 2021-01-19, application granted.

2.Gambhir SS, Cheng Z*, Kothapalli SR, Liu H, “Optical imaging probes, optical imaging systems, methods of optical imaging, and methods of using optical imaging probes”, US10517964B2, 2019-12-31, patent application granted.

3.Cheng Z*, Chen K, Chen X. “Imaging-aided gene therapy using mesenchymal stem cells as target-delivery vehicle”. US9498499B2, 2016-11-22, patent application granted.

4.Cochran JR, Kimura R, Gambhir SS, Cheng Z*. “Imaging methods using engineered integrin binding peptides”, US9265845B2, 2016-02-23, patent application granted.

5.Kimura RH, Gambhir S, Hackel BJ, Teed R, Shen B, Chin F, Cheng Z*. “Cystine knot peptides that bind alpha-v-beta6 integrin”. US9206237B2, 2015-12-08, patent application granted.

6.Cheng Z*, Gambhir SS, Miao Z, Liu H, Ren G. “Imaging probes, methods of making imaging probes, and methods of imaging”, US8753605B2, 2014-06-17, application granted.

7.Bogyo MS, Blum G, Berger A, Cheng Z*, Gambhir SS. “Probes for in vivo targeting of active cysteine proteases”. US8343458B2, 2013-01-01, application granted.

荣誉获奖

2020 全球前2% 科学家榜单

2020 英国皇家化学学会Top 5%高被引学者

2019 英国皇家化学学会普通化学Top 5%高被引学者

2015 教育部长江学者

2012 西门子竞赛导师表彰证书

代表论著

1.Antaris AL, Chen H, Cheng K, Sun Y, Hong G, Qu C, Diao S, Deng Z, Hu X, Zhang B, Zhang X, Yaghi OK, Alamparambil ZR, Hong X*, Cheng Z*, Dai H*. A small-molecule dye for NIR-II imaging. Nature Materials. 2016;15(2):235-42.

2.Hu Z, Fang C, Li B, Zhang Z, Cao C, Cai M, Su S, Sun X, Shi X, Li C, Zhou T, Zhang Y, Chi C, He P, Xia X, Chen Y, Gambhir SS*, Cheng Z*, Tian J*. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows. Nature Biomedical Engineering. 2020, 4, 259-271.

3.Antaris AL, Chen H, Diao S, Ma Z, Zhang Z, Zhu S, Wang J, Lozano AX, Fan Q, Chew L, Zhu M, Cheng K, Hong X*, Dai H*, Cheng Z*. A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nature Communications. 2017;8:15269. doi: 10.1038/ncomms15269. PMID:28524850.

4.Sun X, Xiao Z, Chen G, Han Z, Liu Y, Zhang C, Sun Y, Song Y, Wang K, Fang F, Wang X, Lin Y, Xu L, Shao L, Li J, Cheng Z*, Gambhir SS*, Shen B*. A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management. Science Translational Medicine. 2018;10(431). pii: eaan8840. doi: 10.1126/scitranslmed.aan8840. Liang J#, Wang H#, Ding W, Huang J, Zhou X, Wang H, Dong X, Li G, Chen E, Zhou F, Fan H, Xia J, Shen B, Cai D, Lan P, Jiang H, Ling J, Cheng Z*, Liu X*, Sun J*. Nanoparticle-Enhanced Chemo-immunotherapy to Trigger Robust Antitumor Immunity. Science Advances, 2020, 6(35), eabc3646.

5.Li D, He S, Wu Y, Liu J, Liu Q, Chang B, Zhang Q, Xiang Z, Yuan Y, Jian C, Yu A*, Cheng Z*. Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near-Infrared Window. Advanced Science. 2019;6(23):1902042. doi: 10.1002/advs.201902042.

6.He S, Song J*, Qu J*, Cheng Z*. Crucial Breakthrough of Second Near-infrared Biological Window Fluorophores: Design and Synthesis toward Multimodal Imaging and Theranostics. Chemical Society Review, 2018, 47(12): 4258 – 4278.

7.Hu Z, Chen WH, Tian J*, Cheng Z*. NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic. Trends in Molecular Medicine. 2020; 26(5): 469-482.

8.Chen H, Wang J, Feng X, Zhu M, Hoffmann S, Hsu A, Qian K, Huang D, Zhao F, Liu W, Zhang H*, Cheng Z*. Mitochondria-targeted fluorescent molecules for high efficiency cancer growth inhibition and imaging. Chemical Science, 2019, 10, 7946 – 7951.

9.Shou K, Tang Y, Chen H, Chen S, Zhang L, Zhang A., Fan Q*, Yu A*, Cheng Z*. Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery. Chemical Science, 2018; 9(12): 3105-3110.

10.Sun Y, Zhang X, Xiao Y, Liu, C, Zhu H, Zhou H, Chen Z, Xu F, Wang J, Zhu M, Wu J, Tian M, Zhang H, Deng Z, Cheng Z*, Hong X*. Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chemical Science. 2018;9(8):2092-2097.

社会任职

2021 药品监督管理局放射性药物研究与评价重点实验室学术委员会委员

2021 国际光学工程学会会士

2020 英国皇家化学学会会士

2018 中国核学会放射性药物分会常务委员

2015-2017 中美核医学和分子影像学会主席

2013-2015 中美核医学会和分子影像学会主席候选人、理事会主席

2012-2014 美国核医学及分子影像学会放射性药物委员会董事会董事

2016 Nanomedicine: Nanotechnology, Biology and Medicine 副主编

2013 Frontiers in Physics-Medical Physics and Imaging 副主编；Clinical Cancer Research; Bioconjugate Chemistry; Amino Acids; Anti-Cancer Agents in Medicinal Chemistry; Biophysics Reports; Diagnostics; Frontiers in Nuclear Medicine; Quantitative Imaging in Medicine and Surgery编委

姓名

程震

性别

男

职称

研究员

学历

博士

电话

传真

电子邮件

zcheng@simm.ac.cn

个人主页

主页链接

专家类别

职务

中心主任、课题组长

通讯地址

烟台市牟平区滨海东路198号